An Arbitrary Lagrangian-Eulerian (ALE) formulation is applied in a fully coupled monolithic way, considering the fluid-structure interaction (FSI) problem as one continuum. The mathematical description and the numerical schemes are designed in such a way that general constitutive relations (which are realistic for biomechanics applications) for the fluid as well as for the structural part can be easily incorporated. We utilize the LBB-stable finite element pairs Q2P1 and P+ 2 P1 for discretization in space to gain high accuracy and perform as time-stepping the 2nd order Crank-Nicholson, respectively, a new modified Fractional-Step-q-scheme for both solid and fluid parts. The resulting discretized nonlinear algebraic system is solved by a Newton method which approximates the Jacobian matrices by a divided differences approach, and the resulting linear systems are solved by direct or iterative solvers, preferably of Krylov-multigrid type. For validation and evaluation of the accuracy and performance of the proposed methodology, we present corresponding results for a new set of FSI benchmark configurations which describe the self-induced elastic deformation of a beam attached to a cylinder in laminar channel flow, allowing stationary as well as periodically oscillating deformations. Then, as an example of FSI in biomedical problems, the influence of endovascular stent implantation on cerebral aneurysm hemodynamics is numerically investigated. The aim is to study the interaction of the elastic walls of the aneurysm with the geometrical shape of the implanted stent structure for prototypical 2D configurations. This study can be seen as a basic step towards the understanding of the resulting complex flow phenomena so that in future aneurysm rupture shall be suppressed by an optimal setting of the implanted stent geometry.